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These were tested first in the statistical testing hierarchy, followed by the confirmatory secondary endpoints, which were tested in the following order: achievement of weight loss of at least 10% or 15% at week 104

And with the extension of the duration, the prevalence rate will gradually increase, and the prevalence rate will exceed 90% after 30 years (16, 32)

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10.1007/s00109-015-1310-2 115 RobertiA.FernndezA